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SearchBuildings are significant expansion of medical research facilities on Main Campus in Cleveland
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Cleveland Clinic marked a major milestone in the construction of two research buildings in the Cleveland Innovation District. A ceremonial beam-lifting event celebrated the placement of the two final steel beams in the skyway bridge that will span E. 100th Street, connecting the new facilities.
Cleveland Clinic leaders and researchers signed the beams, sharing messages of hope about the future of research. A significant expansion of laboratory research space on Cleveland Clinic’s Main Campus, the two buildings will total 300,000 square feet at the intersection of E. 100th Street and Cedar Avenue.
Designed to foster innovation and collaboration, the facilities will feature advanced research laboratories, dedicated classroom space, offices and a café as well as enhanced greenspace, landscaping and walking paths that will offer a new entrance to the southeast section of the Main Campus.
“For more than 100 years, Cleveland Clinic has been at the forefront of scientific discovery. These state-of-the-art facilities will provide the infrastructure and technology needed to continue growing Cleveland Clinic’s research efforts,” said Serpil Erzurum, M.D., Cleveland Clinic’s Chief Research and Academic Officer. “They will serve as a vital resource for our research team, empowering them to discover and develop critically needed new treatments.”
The facilities are part of the Cleveland Innovation District, a unique public-private initiative, which brings the State of Ohio and JobsOhio together with Cleveland’s healthcare and higher education institutions to create jobs, accelerate research and educate the workforce of the future.
The northeast building will be approximately 170,000 square feet and home to a variety of research laboratories, including the Sheikha Fatima bint Mubarak Global Center for Pathogen & Human Health Research. The northwest building will be approximately 120,000 square feet, designed for specialty research facilities and core services. Construction began in February 2023 with anticipated completion in November 2025 and March 2026, respectively.
As part of the recent research expansion, Cleveland Clinic opened 45,000 square feet of remodeled space that houses leading-edge laboratories in late 2023. Several of Cleveland Clinic’s fastest-growing research programs are housed in this space, including the Center for Computational Life Sciences, Center for Immunotherapy and Precision Immuno-oncology, and the Center for Therapeutics Discovery.
The project has been partially funded through philanthropic gifts. The buildings were designed by Cleveland Clinic Buildings + Design in collaboration with HOK Architects & Vanderweil Engineers. The construction manager is Gilbane Building.
Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation, Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. Cleveland Clinic is consistently recognized in the U.S. and throughout the world for its expertise and care. Among Cleveland Clinic’s 83,000 employees worldwide are more than 6,600 salaried physicians and researchers, and 21,900 registered nurses and advanced practice providers, representing 140 medical specialties and subspecialties. Cleveland Clinic is a 6,725-bed health system that includes a 173-acre main campus near downtown Cleveland, 23 hospitals, 300 outpatient facilities, including locations in northeast Ohio; Florida; Las Vegas, Nevada; Toronto, Canada; Abu Dhabi, UAE; and London, England. In 2025, there were 15.9 million outpatient encounters, 343,000 hospital admissions and observations, and 336,000 surgeries and procedures throughout Cleveland Clinic’s health system. Visit us at clevelandclinic.org. Follow us at x.com/CleClinicNews. News and resources are available at newsroom.clevelandclinic.org.
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