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SearchCleveland Clinic inventor Stanley Hazen, MD, PhD, shares his groundbreaking research on molecular mechanisms of heart disease and their potential to transform patient care as part of Cleveland Clinic Innovations’ Inventor Chronicle series.
Each episode of the Inventor Chronicles follows a different inventor’s journey, from initial inspiration to life-changing invention.
In this installment of the Inventor Chronicle series, Stanley Hazen, MD, PhD, Section Head of Preventive Cardiology at Cleveland Clinic, shares his groundbreaking research on cardiovascular disease, which extends beyond traditional risk factors like cholesterol, blood pressure, and diabetes. Despite treating these factors, most cardiac events still occur, prompting Dr. Hazen to explore new pathways. His innovative approach involves identifying chemical signatures in blood and urine that can predict future disease, uncovering intriguing connections between gut microbial pathways, artificial sweeteners, and metabolic processes related to niacin metabolism.
One of Dr. Hazen's landmark discoveries is the TMAO pathway, a gut microbial metabolite that he first published in 2011. By reverse engineering this compound, his team identified how gut bacteria produce it and developed enzyme inhibitors that could reduce cardiovascular risks without harming the bacteria. This research suggests that nearly half of heart disease may stem from factors beyond traditional risk factors. Through Cleveland Clinic Innovations, Dr. Hazen is turning these scientific insights into potential diagnostic tests and therapies that could revolutionize patient care and enable more personalized approaches to cardiovascular health.
Join Cleveland Clinic Innovations for the final webinar in the series, Innovation in Action: Revolutionizing Healthcare, where we showcase the transformative power of technologies developed at Cleveland Clinic. This series showcases cutting-edge medical research and highlights pioneering inventors and their groundbreaking inventions.
In the fourth webinar of the series, Cardiometabolic Diagnostics Portfolio, Dr. Hazen will present his groundbreaking study on artificial sweeteners and its implications for cardiometabolic health. Dr. Hazen will delve into his pioneering research, revealing how artificial sweeteners and other biomarkers impact cardiometabolic diagnostics and overall health. Attendees will gain valuable insights into the innovative techniques used to assess and improve cardiometabolic health and the significant implications of his findings. Learn more about the webinar and RSVP here.
Cleveland Clinic Innovations brings the best ideas from the brightest minds in medicine to patients around the world by connecting inventors and their ideas with strategic industry partners to create products that transform the future of healthcare. Since our inception in 2000, Cleveland Clinic Innovations has helped inventors receive 2,700+ patents, executed more than 850 licenses and launched over 100 start-ups to turn ideas into next-generation products for patients.
Watch the full Inventor Chronicle with Stanley Hazen, MD, PhD, here.
