Cleveland Clinic Researchers Uncover How Cancer Stem Cells Drive Triple-Negative Breast Cancer

Cleveland Clinic researchers have published findings in Nature Communications on a new stem cell pathway that allows a highly aggressive form of breast cancer – triple-negative breast cancer – to thrive. Hormone therapy for breast cancer blocks cancer cells from interacting with hormones such as estrogen and progesterone, which fuel the cancer cells to grow … Read More

New Research Aims to Improve the Lives of Children with High Grade Glioma

Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine has been awarded a $100,000 Josh Metzger Memorial Fox Trot Grant sponsored by the Prayers From Maria Foundation, in support of pediatric neurosurgical oncology research. Violette Recinos, M.D., director of pediatric neurosurgical oncology at the Cleveland Clinic, and her team will use the … Read More

Cleveland Clinic Researchers Reveal Biomarker for Guiding Prostate Cancer Treatment

Back-to-back discoveries from Cleveland Clinic demonstrate for the first time how a testosterone-related genetic abnormality can help predict individual patient responses to specific prostate cancer therapies. The studies, published in the October 12 issue of JAMA Oncology, suggest that men who inherit this variant would benefit from a personalized treatment plan that targets specific hormonal … Read More

Cleveland Clinic Researchers Discover Similarities Between Next-Generation Prostate Cancer Drugs

  Cleveland Clinic researchers have shown for the first time how a class of advanced prostate cancer drugs are processed in the body and how their anti-tumor activity might change depending on how they are metabolized. Their pre-clinical findings, just published in Cell Chemical Biology, may lay the foundation for improving therapies for treatment-resistant, aggressive … Read More

Cleveland Clinic Research Shows Time to Initiating Cancer Therapy Is Increasing, Associated With Worsened Survival

After reviewing nearly 3.7 million patient records, Cleveland Clinic researchers have shown that newly diagnosed cancer patients are having to wait longer to begin treatment, a delay that is associated with a substantially increased risk of death. The researchers used prospective data from the National Cancer Database and examined the number of days between diagnosis … Read More