Cleveland Clinic Researchers Reveal Biomarker for Guiding Prostate Cancer Treatment

Back-to-back discoveries from Cleveland Clinic demonstrate for the first time how a testosterone-related genetic abnormality can help predict individual patient responses to specific prostate cancer therapies. The studies, published in the October 12 issue of JAMA Oncology, suggest that men who inherit this variant would benefit from a personalized treatment plan that targets specific hormonal … Read More

Cleveland Clinic Researchers Discover Similarities Between Next-Generation Prostate Cancer Drugs

  Cleveland Clinic researchers have shown for the first time how a class of advanced prostate cancer drugs are processed in the body and how their anti-tumor activity might change depending on how they are metabolized. Their pre-clinical findings, just published in Cell Chemical Biology, may lay the foundation for improving therapies for treatment-resistant, aggressive … Read More

Cleveland Clinic Research Shows Time to Initiating Cancer Therapy Is Increasing, Associated With Worsened Survival

After reviewing nearly 3.7 million patient records, Cleveland Clinic researchers have shown that newly diagnosed cancer patients are having to wait longer to begin treatment, a delay that is associated with a substantially increased risk of death. The researchers used prospective data from the National Cancer Database and examined the number of days between diagnosis … Read More

Cleveland Clinic Researchers Discover Opportunities to Overcome Cancer Treatment Resistance

A collaborative Cleveland Clinic, University of Oxford and Moffitt Cancer Center team of researchers has proven the theory that, while resistance to targeted treatment in cancer is truly a moving target, there are opportunities to overcome the resistance that develops. Though more study is needed, researchers believe understanding and predicting tumor resistance may translate into … Read More

Cleveland Clinic Researcher Receives Top Ten Clinical Research Achievement Award

Cleveland Clinic physician-researcher Nima Sharifi, M.D. was recognized as a Top Ten Clinical Research Achievement awardee by the Clinical Research (CR) Forum, a national organization of senior researchers and thought leaders from the nation’s leading academic health centers. Dr. Sharifi was selected for his research published in the October 2016 edition of The Lancet Oncology, … Read More