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August 8, 2018/News Releases

Cleveland Clinic Researchers Receive $4.7M NIH Grant to Prevent Cancer-Associated Thrombosis

Consortium aims to develop strategies to reduce life-threatening side effect of cancer therapy

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The National Heart, Lung and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $4.7 million grant to Cleveland Clinic to study the prevention of life-threatening, cancer-associated blood clots.

The new funding will support a Cleveland Clinic-led research consortium, which will focus on developing strategies to prevent cancer-associated thrombosis (blood clot formation), a potential side effect of cancer treatment.

The five-year grant, led by Keith McCrae, M.D., and Alok Khorana, M.D., supports the creation of a new risk assessment tool to better predict which cancer patients will develop blood clots during treatment. The project, led by Cleveland Clinic’s Taussig Cancer Institute and Lerner Research Institute, will coordinate a consortium of three sites involved in this NHLBI program. Other sites include Beth Israel Deaconess Medical Center (Harvard Medical School) and the University of Cincinnati.

“About 20 percent of cancer patients develop blood clots, which can cause stroke, hospitalization and delays in treatment. In fact, cancer-associated thrombosis is the second leading cause of death in patients with cancer,” said Dr. Khorana, director of the gastrointestinal malignancies program at the Taussig Cancer Institute. “This grant will help us address the challenge of identifying who will develop blood clots and enable us to treat them proactively with blood thinners to prevent this complication.”

The study will incorporate data from more than 5,000 patients with colorectal, lung and pancreatic cancer enrolled in clinical trials at various research centers. Researchers will use this robust biobank to identify coagulation-related and genetic biomarkers associated with abnormal blood clotting. They will build on research that suggests that activation of a specific blood-clotting pathway may contribute to thrombosis, and that biomarkers related to that pathway may identify patients at particularly high risk of blood clots before they happen.

The team ultimately plans to synthesize this data to develop a comprehensive risk calculator by incorporating the identified biomarkers and statistical modeling. The online risk assessment tool would be available for clinical use.

“Cancer-associated blood clots are a critical clinical problem, and we urgently need better ways to predict which patients are at greatest risk,” said Dr. McCrae, director of hematology at the Taussig Cancer Institute. “This NHLBI grant will provide new information that will greatly improve the management of patients with cancer, arming physicians with an advanced statistical tool to better identify who may develop this common and harmful side effect.”

The new grant builds upon important work initiated through Cleveland Clinic’s Center of Excellence in Cancer Thrombosis Research, which focuses on novel approaches to the management and prevention of cancer-associated thrombosis. Since its establishment in 2016, a multidisciplinary team of researchers across Cleveland Clinic, with collaborators at Case Western Reserve University, have worked together to study the efficacy of novel therapies, develop new preclinical models, and create and expand biorepositories. Dr. Khorana’s work is supported by the Sondra and Stephen Hardis Chair in Oncology Research.

About Cleveland Clinic

Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. Cleveland Clinic is consistently recognized in the U.S. and throughout the world for its expertise and care. Among Cleveland Clinic’s 81,000 employees worldwide are more than 5,743 salaried physicians and researchers, and 20,160 registered nurses and advanced practice providers, representing 140 medical specialties and subspecialties. Cleveland Clinic is a 6,690-bed health system that includes a 173-acre main campus near downtown Cleveland, 23 hospitals, 276 outpatient facilities, including locations in northeast Ohio; Florida; Las Vegas, Nevada; Toronto, Canada; Abu Dhabi, UAE; and London, England. In 2023, there were 13.7 million outpatient encounters, 323,000 hospital admissions and observations, and 301,000 surgeries and procedures throughout Cleveland Clinic’s health system. Patients came for treatment from every state and 132 countries. Visit us at clevelandclinic.org. Follow us at twitter.com/CleClinicNews. News and resources available at newsroom.clevelandclinic.org.

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