Cleveland Clinic First in the World to Use Latest Ablation Technology to Destroy Large Liver Tumors

First patient had a 2.4-inch tumor successfully treated with the minimally invasive procedure 

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Eren Berber, M.D., led a Cleveland Clinic team that is the first in the world to use a recently FDA-approved ablation technology that can destroy large liver tumors.

Cleveland Clinic is the first hospital in the world to use a recently FDA-approved ablation technology that can destroy large liver tumors. The minimally invasive procedure uses a single needle connected to a powerful 150-watt microwave generator that can burn a malignant liver tumor as large as 2.4 inches, which is about the size of an egg.

Eren Berber, M.D., director of Cleveland Clinic’s Surgical Liver Tumor Ablation Program, led a team that successfully used the technology in October to treat a patient who had a 2.4-inch liver tumor. Following the minimally invasive procedure, the patient is doing well and the post-operative scan shows no trace of the tumor.

To perform the procedure, a laparoscopic camera and an ultrasound probe to locate the tumor are inserted in the abdomen through two small incisions. Under laparoscopic guidance, a microwave needle is inserted through the skin into the liver tumor. When ready, the generator is powered on to deliver heat that burns and destroys the lesion.

Advances in minimally invasive liver surgery and ablation technologies continue to offer new treatment options for patients who have large malignant liver tumors and are not good candidates for open liver surgical procedures that are associated with longer operative times and hospital stays, as well as higher incidence of complications.

“The goal is to offer the best treatment option for patients depending on their unique health condition. In the hands of an experienced surgical team, the laparoscopic ablation technique benefits the patient, who experiences better postoperative recovery, less pain, a quicker return to normal life, and a lower risk of an incisional hernia compared with traditional open surgery,” said Dr. Berber, with Cleveland Clinic’s Endocrinology & Metabolism Institute and Digestive Disease & Surgery Institute.

Cleveland Clinic has been using ablation technologies to treat smaller tumors that are about 1.5 inches in diameter and not amenable to liver resection. To date, Dr. Berber has performed one of the largest surgical laparoscopic series in the world using advanced ablation technologies to destroy liver tumors. Left untreated, malignant liver tumors can progress and lead to symptoms of liver disease, and even liver failure.

Since the first case in October at Cleveland Clinic, Dr. Berber and his team have successfully treated three more patients with large liver tumors.

Dr. Berber has a consulting agreement with Medtronic and has received honoraria for consulting activities.  His consulting agreements do not affect his choice of the best treatment option for his patients.

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Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. Cleveland Clinic is consistently recognized in the U.S. and throughout the world for its expertise and care. Among Cleveland Clinic’s 77,000 employees worldwide are more than 5,658 salaried physicians and researchers, and 19,000 registered nurses and advanced practice providers, representing 140 medical specialties and subspecialties. Cleveland Clinic is a 6,699-bed health system that includes a 173-acre main campus near downtown Cleveland, 23 hospitals, more than 275 outpatient facilities, including locations in northeast Ohio; southeast Florida; Las Vegas, Nevada; Toronto, Canada; Abu Dhabi, UAE; and London, England. In 2022, there were 12.8 million outpatient encounters, 303,000 hospital admissions and observations, and 270,000 surgeries and procedures throughout Cleveland Clinic’s health system. Patients came for treatment from every state and 185 countries. Visit us at Follow us at News and resources available at

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