Cleveland Clinic Researchers Reveal Biomarker for Guiding Prostate Cancer Treatment

Back-to-back discoveries from Cleveland Clinic demonstrate for the first time how a testosterone-related genetic abnormality can help predict individual patient responses to specific prostate cancer therapies. The studies, published in the October 12 issue of JAMA Oncology, suggest that men who inherit this variant would benefit from a personalized treatment plan that targets specific hormonal … Read More

Cleveland Clinic Researchers Discover Similarities Between Next-Generation Prostate Cancer Drugs

  Cleveland Clinic researchers have shown for the first time how a class of advanced prostate cancer drugs are processed in the body and how their anti-tumor activity might change depending on how they are metabolized. Their pre-clinical findings, just published in Cell Chemical Biology, may lay the foundation for improving therapies for treatment-resistant, aggressive … Read More

Cleveland Clinic-led Study Finds That New Blood Test is More Accurate in Predicting Overall Risk of Prostate Cancer than Standard Prostate-Specific Antigen (PSA)

A team of researchers from Cleveland Clinic, Louis Stokes Cleveland VA Medical Center, Kaiser Permanente Northwest, and other clinical sites have demonstrated that a new blood test known as IsoPSA detects prostate cancer more precisely than current tests in two crucial measures – distinguishing cancer from benign conditions, and identifying patients with high-risk disease. By … Read More

Cleveland Clinic Researcher Receives Top Ten Clinical Research Achievement Award

Cleveland Clinic physician-researcher Nima Sharifi, M.D. was recognized as a Top Ten Clinical Research Achievement awardee by the Clinical Research (CR) Forum, a national organization of senior researchers and thought leaders from the nation’s leading academic health centers. Dr. Sharifi was selected for his research published in the October 2016 edition of The Lancet Oncology, … Read More

Cleveland Clinic Researchers Reverse Prostate Cancer Drug Resistance

A Cleveland Clinic research team has uncovered a biological pathway that renders a common prostate cancer drug useless and, for the first time, restored the drug’s cancer-killing power in human prostate cancer tumor cells grown in mice. Results from the study were published online today in the medical journal, eLife. Resistance to prostate cancer drugs … Read More