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SearchCollaboration brings together Cleveland Clinic’s expertise in clinical excellence and biomedical research with Khosla Ventures’ 20+ years of investing at the intersection of health and technology
Cleveland, Ohio, and Menlo Park, California: Cleveland Clinic and Khosla Ventures today announced a strategic collaboration that connects the international health system with one of Silicon Valley’s leading investors in healthcare and technology.
The new relationship combines the organizations’ unique strengths, aiming to reimagine healthcare delivery and create solutions that address some of the most pressing challenges in the field.
As part of the collaboration, Khosla Ventures portfolio companies can work with Cleveland Clinic providers to showcase and test new technologies at all stages — from clinical validation to commercial adoption. This access gives startups a distinct advantage to demonstrate value directly with clinicians, accelerating the journey from early, bold ideas to proven, scalable solutions.
For Cleveland Clinic, the collaboration provides a direct pipeline to emerging technologies in areas such as artificial intelligence, digital health, and next-generation therapeutics.
“Khosla Ventures invests in early, bold, and impactful ideas that help people get healthy, stay healthy, and live longer,” said Hal Paz, MD, operating partner at Khosla Ventures and former CEO of multiple large-scale health systems. “AI is the most transformative technology of our lifetime, and its impact on healthcare will be massive. This relationship with Cleveland Clinic — one of the most respected health institutions in the world — gives our companies an advantage to validate and scale their innovations.”
“This collaboration pairs our health system’s expertise in biomedical research, clinical care and innovation with Khosla Ventures’ venture expertise and network of entrepreneurs to drive meaningful advancements in the healthcare industry,” said Geoff Vince, PhD, Chief, Cleveland Clinic Innovations. “Together we aim to accelerate transformational innovation, foster groundbreaking technologies, and ultimately improve patient outcomes.”
Early Commercial Traction
As part of the collaboration, Cleveland Clinic has already entered into customer agreements and commercial relationships with Khosla-backed companies, as well as currently evaluating several others for potential commercial partnerships, investments, and co-development opportunities. Both organizations are also working together to identify and incubate promising Cleveland Clinic research and innovation opportunities that could lead to the creation of new companies.
Joint Incubation
Cleveland Clinic and Khosla Ventures also announced they are exploring opportunities to jointly incubate a new company. Khosla Ventures will lead technical development and recruiting, while Cleveland Clinic plans to provide the clinical environment to test, refine, and scale the service.
Strategic Focus Areas
Through the collaboration, the organizations plan to prioritize the following areas where technology can have a transformative impact on health and longevity including:
The partnership will be supported by Cleveland Clinic Innovations (CCI), the health system’s innovation arm, which has transformed more than 900 technologies into licensed products and launched more than 100 spin-off companies since 2000. CCI brings deep experience in IP management, licensing, and startup incubation, making it a strategic partner in guiding new ideas from concept to commercialization.
The new collaboration was announced at Cleveland Clinic Life Science Summit on October 14 in London.
Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. Cleveland Clinic is consistently recognized in the U.S. and throughout the world for its expertise and care. Among Cleveland Clinic’s 82,600 employees worldwide are more than 5,786 salaried physicians and researchers, and 20,700 registered nurses and advanced practice providers, representing 140 medical specialties and subspecialties. Cleveland Clinic is a 6,728-bed health system that includes a 173-acre main campus near downtown Cleveland, 23 hospitals, 280 outpatient facilities, including locations in northeast Ohio; Florida; Las Vegas, Nevada; Toronto, Canada; Abu Dhabi, UAE; and London, England. In 2024, there were 15.7 million outpatient encounters, 333,000 hospital admissions and observations, and 320,000 surgeries and procedures throughout Cleveland Clinic’s health system. Patients came for treatment from every state and 112 countries. Visit us at clevelandclinic.org. Follow us at x.com/CleClinicNews. News and resources are available at newsroom.clevelandclinic.org.
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Khosla Ventures is a venture capital firm focused on investments in artificial intelligence, financial services, healthcare, consumer, enterprise, and sustainability. It is known for making early capital investments in startups such as OpenAI, Guardant Health, Instacart, Affirm, DoorDash, and Block.
