Jae Jung, Ph.D., Appointed as Chair of Cleveland Clinic Lerner Research Institute’s Department of Cancer Biology

Jung also to serve as director of Center for Global and Emerging Pathogens Research

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Jae Jung, Ph.D.

Cleveland Clinic has appointed Jae Jung, Ph.D., chair of Lerner Research Institute’s Department of Cancer Biology. Jung will also serve as director of the new Center for Global and Emerging Pathogens Research, which will focus on public health threats ranging from the Zika virus to SARS-CoV-2 (which causes COVID-19).

Jung is an internationally renowned expert in virology and virus-induced cancers who has broken ground in the field of inflammation, immune-oncology and emerging pathogens.

As chair of Cancer Biology, he will lead the department’s work in understanding the biological underpinnings of cancer ranging from genetic and molecular pathways to disease manifestation. The department is home to leaders in the field of several cancer research areas including prostate cancer, glioblastoma and stem cells. He will closely collaborate with cancer researchers across Northeast Ohio and Cleveland Clinic, including the new Center for Immunotherapy and Precision Immuno-Oncology.

Jung’s cancer research focuses on virus-induced cancers, including Kaposi’s sarcoma, the most common tumor in patients with AIDS. For his work in this disease area, the National Cancer Institute awarded him the prestigious Outstanding Investigator Award in 2016.

Jung will also lead the Center for Global and Emerging Pathogens Research, which is focused on broadening understanding of emerging pathogens. The center spans Lerner Research Institute and the Cleveland Clinic Florida Research and Innovation Center in Port St. Lucie, Florida.

“Jae Jung is a brilliant and global leader in research into the deep and complex intersections between the immune system and cancer,” said Serpil Erzurum, M.D., chair of Lerner Research Institute. “His work has defined how viruses induce cancers, which make up to 25% of cancers in the world. It is quite fortuitous at this time that we have recruited a world-class scientist in cancer and virus research, propelling our teams in Cleveland and Florida forward in both of these significant areas.”

Jung has several research projects related to coronaviruses, including vaccine and drug development and has developed one of the first preclinical models to study SARS-CoV-2 infection and transmission to lead to development of a COVID-19 vaccine. His vaccine work utilizes nanoparticles that compel the coronavirus to use its own surface protein to produce antibodies that block viral infection. The hope is that this approach will have fewer side effects than other vaccines, especially among the older population that is particularly susceptible to COVID-19.

Jung and a multi-disciplinary team of scientists and clinicians in Ohio and Florida are collaborating to uncover the mechanisms of infectious agents and virus-induced cancers. He will lead virology, immunology and oncology researchers working to make laboratory discoveries about how pathogens spread and cause disease and will collaborate with Cleveland Clinic’s Center for Therapeutics Discovery. He recently received a $2.8 million grant from National Institutes of Health to develop a vaccine for a newly emerging tick-borne disease.

“Jae Jung is a foremost authority in virus-related cancer and immunology who will build and grow our research programs to advance science and ultimately improve care for our patients,” said Brian Bolwell, M.D., chairman of Taussig Cancer Institute and the Cleveland Clinic Cancer Center. “He will bring together a team of experts to better understand the complexities of these cancers and emerging pathogens to develop critically needed treatments and vaccines.”

“I am excited to collaborate with Cleveland Clinic’s experts in immunotherapy, oncology and infectious disease to advance our knowledge of immunologic medicine,” said Jung. “Cleveland Clinic’s robust clinical and research infrastructure in Cleveland as well as at the new Florida Research and Innovation Center will enable us to develop innovative and novel approaches for new therapeutics and vaccines and make them available to people around the world.”

Jung joins Cleveland Clinic from the University of Southern California, where he was chair of Molecular Microbiology and Immunology and director of the Institute of Emerging Pathogens and Immune Diseases.  He earned his Ph.D. in microbiology from the University of California, Davis. He completed post-doctoral training and was later promoted to professor at Harvard Medical School. He is an elected fellow of the American Association for the Advancement of Science and the American Academy of Microbiology.

About Cleveland Clinic
Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. U.S. News & World Report consistently names Cleveland Clinic as one of the nation’s best hospitals in its annual “America’s Best Hospitals” survey. Among Cleveland Clinic’s 72,500 employees worldwide are more than 5,050 salaried physicians and researchers, and 17,800 registered nurses and advanced practice providers, representing 140 medical specialties and subspecialties. Cleveland Clinic is a 6,500-bed health system that includes a 173-acre main campus near downtown Cleveland, 21 hospitals, more than 220 outpatient facilities, including locations in northeast Ohio; southeast Florida; Las Vegas, Nevada; Toronto, Canada; Abu Dhabi, UAE; and London, England. In 2021, there were 10.2 million total outpatient visits, 304,000 hospital admissions and observations, and 259,000 surgical cases throughout Cleveland Clinic’s health system. Patients came for treatment from every state and 185 countries. Visit us at clevelandclinic.org. Follow us at twitter.com/ClevelandClinic. News and resources available at newsroom.clevelandclinic.org.

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